Black Decker Unveils Their New Thermal Leak Detector

first_img( — Now you can find and plug up those leaks around your home once and for all. Black & Decker is offering an innovative leak detector, in about a month and will be price at around $39.99. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The detector works by simply pointing it at walls, windows, molding, and outlets in your home and determines leaks through color signals. A green light indicates regular temperature, red light shows hot spots, and a blue spot shows you the exact place where cold air is bursting in. Black & Decker claims their detector can catch temperature changes by as little as one degree Fahrenheit. The thermal leak detector has a user select switch to differentiate between 1, 5 or 10 degree F changes. According to Energy Star, plugging up leaks and drafts in your home can scythe up to 20-percent from your heating bills; your leak detector will pay for itself. The Black & Decker Thermal Leak Detector is listed as “coming soon” at the company’s online store, where it retails for $39.99. Considering that the gadget will only cost around $40 when it becomes available in a month, it should be a big cash-saver when cutting down your heating cost in the winter months.© 2008 Black & Decker Thermal Leak Detector Explore further Inexpensive Detector Sees the Invisible, In Color Citation: Black & Decker Unveils Their New Thermal Leak Detector (2008, December 12) retrieved 18 August 2019 from read more

Study shows prehuman ancestors adapted to metabolize ethanol long before humans learned

first_imgCredit: Ben Mills via Wikimedia Commons Humans have been consuming beverages that make them tipsy, drunk and/or sick for a very long time, of that there is little doubt. But why do we have the ability to metabolize ethanol in the first place? That’s what the team set out to answer. They began by sequencing an enzyme called ADH4—it’s what’s responsible for allowing us to metabolize ethanol. Other primates have it as well, but not all metabolize ethanol as well as we do. By sequencing ADH4 found in a 28 mammal species including 17 that were primates, the team was able to create a family tree of sorts based on ethanol metabolizing ability. The team then tested those sequences for their metabolizing ability by synthesizing nine kinds of the ADH4 enzyme. Doing so showed the researchers that most early primates had very little ability to metabolize ethanol for most of their early history.Then, about 10 million years ago, some of the ancestors of modern humans suddenly were able to do a much better job of it, while others that diverged and led to apes such as orangutans, did not. This discovery led the team to wonder what might have occurred to cause this to come about. They note that other evidence has shown that around this same time, the planet cooled slightly, making life a little more difficult for our tree dwelling ancestors. They suggest they began climbing down out of the trees to eat the fruit that fell, which gave them a food advantage and a reason for developing the ability to metabolize ethanol—otherwise they would have become too drunk from eating the fermenting fruit to defend themselves or live otherwise normal lives. If true, the theory would also offer a major clue as to why our ancestors became terrestrial. Study unlocks secret of how fruit flies choose fruit with just the right amount of ethanol (—A team of researchers in the U.S. has found evidence to support the notion that our pre-human ancestors were able to metabolize ethanol long before our later ancestors learned to take advantage of fermentation—to create alcoholic beverages. In their paper published in Proceedings of the National Academy of Sciences, the team describes how they genetically sequenced proteins from modern primates and used what they found to work backwards to discover just how long ago our ancestors have been able to metabolize ethanol. Journal information: Proceedings of the National Academy of Sciences Explore furthercenter_img © 2014 Citation: Study shows pre-human ancestors adapted to metabolize ethanol long before humans learned about fermentation (2014, December 2) retrieved 18 August 2019 from More information: Hominids adapted to metabolize ethanol long before human-directed fermentation, PNAS, Matthew A. Carrigan, DOI: 10.1073/pnas.1404167111AbstractPaleogenetics is an emerging field that resurrects ancestral proteins from now-extinct organisms to test, in the laboratory, models of protein function based on natural history and Darwinian evolution. Here, we resurrect digestive alcohol dehydrogenases (ADH4) from our primate ancestors to explore the history of primate–ethanol interactions. The evolving catalytic properties of these resurrected enzymes show that our ape ancestors gained a digestive dehydrogenase enzyme capable of metabolizing ethanol near the time that they began using the forest floor, about 10 million y ago. The ADH4 enzyme in our more ancient and arboreal ancestors did not efficiently oxidize ethanol. This change suggests that exposure to dietary sources of ethanol increased in hominids during the early stages of our adaptation to a terrestrial lifestyle. Because fruit collected from the forest floor is expected to contain higher concentrations of fermenting yeast and ethanol than similar fruits hanging on trees, this transition may also be the first time our ancestors were exposed to (and adapted to) substantial amounts of dietary ethanol This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Reprogramming the oocyte

first_img Explore further More information: Oocyte Factors Suppress Mitochondrial Polynucleotide Phosphorylase to Remodel the Metabolome and Enhance Reprogramming, Cell Reports, Volume 12, Issue 7, p1080–1088, 18 August 2015. factors not only drive somatic cell nuclear transfer reprogramming but also augment the efficiency and quality of induced pluripotent stem cell (iPSC) reprogramming. Here, we show that the oocyte-enriched factors Tcl1 and Tcl1b1 significantly enhance reprogramming efficiency. Clonal analysis of pluripotency biomarkers further show that the Tcl1 oocyte factors improve the quality of reprogramming. Mechanistically, we find that the enhancement effect of Tcl1b1 depends on Akt, one of its putative targets. In contrast, Tcl1 suppresses the mitochondrial polynucleotide phosphorylase (PnPase) to promote reprogramming. Knockdown of PnPase rescues the inhibitory effect from Tcl1 knockdown during reprogramming, whereas PnPase overexpression abrogates the enhancement from Tcl1 overexpression. We further demonstrate that Tcl1 suppresses PnPase’s mitochondrial localization to inhibit mitochondrial biogenesis and oxidation phosphorylation, thus remodeling the metabolome. Hence, we identified the Tcl1-PnPase pathway as a critical mitochondrial switch during reprogramming. Citation: Reprogramming the oocyte (2015, August 26) retrieved 18 August 2019 from Reprogramming in the Egg. Credit: Journal information: Cell Reports (—Among other things, the egg is optimized to process the sperm genome. The cytoplasmic factors that make this possible also give the egg the ability to reprogram the nuclei from other kinds of cells if these nuclei are swapped into the egg. Although this ‘somatic cell nuclear transfer’ is a handy way to generate pluripotent cells (cells very similar to embryonic stem cells, or even clones like Dolly), there is significant logistical and ethical overhead to the procedure. The alternative is to take the ‘transcription factor’ or iPSC reprogramming approach which attempts to induce a pluripotent state from only partial knowledge of the full method used by the eggcenter_img The magic four set of transcription factors (Oct4, Sox2, Myc and Klf4), while just a subset of the class of maternal effect genes, are sufficient to make passable iPSCs. However, as a group of researchers from Singapore note in a recent Cell Reports paper, the main drawback is that they are less efficient at establishing complete, bona fide pluripotency. To try to improve this situation, the researchers screened 20 oocyte-enriched genes for their ability to further induce iPSC reprogramming of mouse fibroblasts which already expressed retroviral versions of the above factors.The only factors that worked—ie. significantly increased the number of alkaline phosphatase positive iPSC colonies—were members of the T-cell leukemia (Tcl1) protein family. The researchers found that Tcl1’s main partner in the cell is an RNA-binding protein called mitochondrial polynucleotide phosphorylase (PnPase). So now things can begin to get interesting. PnPase is a bifunctional enzyme with both exoribonuclease and oligonucleotide polymerase activity. In other words it can dismantle RNA chains and also long heteropolymeric tails.In addition to their own RNA products, mitochondria are noted importers of various nuclear-encoded tRNAs as well the essential aminoacyl-tRNA synthetases. Mitochondrial RNA-binding proteins like PnPase are believed to be critical in the import and processing of RNAs in mitochondria. The author’s finding that egg factors can reprogram metabolism by suppressing mitochondrial PnPase has far more general implications for stem cells. For example, although somatic cells rely on oxidative phosphorylation, pluripotent cells preferentially use glycolysis as an energy source and typically have immature mitochondria. Recent work now indicates that the main role of electron transport in proliferating cells, both in development or in cancer, may simply be for the synthesis of aspartate. A new appreciation for the apportioning of mitochondria, again in development of the egg during the so-called germline bottleneck, later in germ cell specification, and in cancer unifies these concepts.The suppression of mitochondrial biogenesis via the Tcl1-PnPase ‘switch’ is just one mechanism the researchers explored. They also found that a closely related homolog, Tcl1b1, could significantly boost the fibroblast somatic reprogramming. They note that PnPase is critical, at least in mice, not only for embryogenesis but for ear, muscle and brain development. They even suggest PnPase could be an important factor in new mitochondrial replacement therapies. Singapore scientists discover rejuvenation factors © 2015 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Joining Hands for mood art

first_imgThe exhibition is organised by IKA art, from December 7 and will continue till December 12, curated by Gaurav Chawla, Ruchi Chadha and Sumita Kathuria at the open palm court Gallery, India Habitat Centre.In a society we all are Individuals but collectively we play a role to upgrade and for betterment of the society. Collectively we can make an impact and do wonders, till being Individuals with an individual and unbiased view point . It is a Show to prove that being collectively as a group , yet independent in approach we can work together in a progressive society and contribute to make it better for all. Also Read – ‘Playing Jojo was emotionally exhausting’Participating Artist- Bharti Chopra, Amol Satre, Gaurav Chawla, Harminder Bhoparai, Neeru Suri, Kapil Kapoor, Kaniska Oswal GUpta, Jyoti Lahiri,Praveen Verma, Ruchi chadha, Shrish v.mitwkar, Sumita kathuria, Tara S.A part of the sale proceeds of the art works will go to Svackshee Sansthan, Alvar, a NGO promoting girl child education in Mewal region of Alvar, Rajasthan , India.When: On till December  12 Where: Open palm court Gallery, India Habitat Centre, Lodhi Roadlast_img read more

Peoples power in Chhattisgarh

first_imgRESIDENTS OF coal-rich Gare village in Chhattisgarh’s Raigarh district have found a unique way to assert their rights over the natural resources found on their land—they have floated a company to mine coal and generate power. Inspired by Mahatma Gandhi’s principles of self-sufficiency and non-violence, the residents started Gare Urja Private Limited in June 2013. Registered in Gwalior, Madhya Pradesh, the company today has more than 250 farmers from 10 villages as shareholders. The farmers own 450 hectares that fall in the coal block, Gare IV/6, which holds high-quality coal. The idea of floating a cooperative mining company was born in 2006, when the Centre allocated the block to Jindal Steel Works (JSW) despite opposition from the residents. And this was not a one-off instance in the coal-rich Tamnar taluka. “In the past few years, the Centre has allocated land in Gare and its adjoining villages to coal mining, power and steel companies, such as Jindal, Jaiswal Neco and Monnet-Ispat, against people’s consent,” alleges Harihar Patel, former sarpanch of Gare.  Also Read – Gateway of criminal justiceInterestingly, Gare IV/6 is one of the 218 coal blocks whose mining leases were cancelled by the Supreme Court in August this year because of their arbitrary allocation (see ‘Coal quandary’, Down To Earth, September 16-30, 2014). Residents say the Centre’s decision to allocate the coal block to a private firm without their consent is also illegal as per the Supreme Court judgement on July 23, 2013, which states that the owner of land has absolute rights over the minerals under or over it. The 2013 Supreme Court order was passed on a petition filed by a group of Kerala farm owners who challanged a Kerala High Court verdict which said the state had rights over natural resources in private land. “After forming the company, we are now ready to bid for coal blocks underneath our own land once the Centre opens an allocation bid,” says Patel, one of the 10 directors of Gare Urja. Also Read – Turning a blind eyeCoal satyagrahaThough the Gare residents are yet to earn from the natural resource underneath their land, they have begun asserting their rights over it. Since 2013, they have been celebrating birth anniversary of Gandhi by staging coal satyagraha. This year, over 700 residents, including 500 women, met at the village temple in the morning and marched to the bank of the Keloriver, a tributary of the Mahanadi. After a community feast, the group collected coal from an exposed seam and marched on to submit the pieces at the agricultural market cooperative office in Gare in the presence of government officials. “It was a protest against companies that forcefully wanted to acquire people’s land to mine coal,” says Patel, also a member of Jan Chetna Manch, a non-profit working for the rights of people affected by mining. Rajesh Tripathi, land rights activist with Jan Chetna Manch, says the satyagraha is a departure from the previous protest in 2008 that had turned violent. On January 5, 2008, JSW had called for a public hearing, a requirement to get environmental clearance. But residents staged protests at the hearing. In response, the police lathi-charged the crowd, leaving 122 people wounded and 22 critically injured, says Tripathi.The residents then moved the National Green Tribunal (NGT) contesting the public hearing. In 2011, NGT termed the public hearing illegal and asked JSW to organise another public hearing. By that time, the residents of Gare had got organised and the idea of floating their own company had gained ground.Good economic senseA hectare of agricultural land in and around Gare holds coal reserves worth Rs 55 crore, says Mishra. But JSW was offering only Rs 10 lakh per hectare to the land owners. “This is when our calculation shows that after paying royalty and other taxes, a farmer can earn up to Rs 11,000 per 2.5 tonnes of coal mined from his land. This translates into an income of about Rs 3 lakh per month. So why do we need a company to come and mine here?” he asks. Between 2012 and 2013, Delhi-based non-profit Mines, Mineral and People organised a series of workshops in Gare, sensitising the residents about their land rights, cost of coal and power.The cooperative mining business model, Mishra and Patel agree, is far more sustainable and can take care of local energy needs. Mishra points out that a community mining company similar to that of Gare is already successfully operating in Jharkhand’s Dumka town. A three kilo-Watt power plant is operating with coal mined by villagers. It generates enough electricity to light up houses and run fans in the surrounding villages, says Mishra.Gare Urja will soon carry out its first audit. Directors have shelled out Rs 10,000 each to form a corpus, while their accountant recently informed that a Permanent Account Number for the company has been allotted by the Income Tax department. “We have collected about Rs 10,000 each from 10 directors as a corpus to start the company, while land would be used as collateral to raise money to start mining,” says Patel.    DOWN TO EARTHlast_img read more

RDay tableaux to showcase nations finest initiatives

first_imgDepicting India’s vivid art and culture, contribution to science and technology and Prime Minister Narendra Modi’s Jan Dhan Yojna as well as Make In India campaigns, a total of 25 tableaux will roll down Rajpath at this year’s Republic Day parade.The tableaux were displayed here Thursday.Up from last year’s 18, this year 16 of the tableaux will represent different states while nine will be from different ministries and government departments.The Department of Financial Services’ tableau on the Pradhan Mantri Jan Dhan Yojana will highlight the uniqueness of the campaign and its impact on the weaker sections and low income groups. Also Read – ‘Playing Jojo was emotionally exhausting’The Make in India tableau by the Department of Industrial Policy and Promotion will depict a mechanised lion set against the background of a smart city.A replica of the Statue of Unity — another pet project of Modi — that pays tribute to Sardar Vallabhbhai Patel will be displayed in the tableau of Gujarat, the prime minister’s home state.“The tableaux will show India’s varied cultural diversity, development in science and technology and recent campaigns launched by the government,” defence ministry spokesman Dhananjay Mohanty said. The defence ministry organises the parade. Also Read – Leslie doing new comedy special with NetflixThe newly formed state of Telangana will be making its debut in the parade showcasing Mahakali, the divine mother goddess of the region.States like Jammu and Kashmir and Arunachal Pradesh would be showcasing their popular folk dances.Chhattisgarh, Andhra Pradesh and Madhya Pradesh would be promoting the festivals of Dussehra, Sankranti Sambaraalu (Makar Sankranti) and Bhagoria (festival of love and match making) respectively.Uttar Pradesh will pay tribute to the 10th and last Nawab of Awadh Wajid Ali Shah and the tableau will have live Kathakali dancers as the dance was performed by the nawab himself in the temples of Awadh.Over 1,400 artistes, fabricators, designers and visualisers were involved in the making of the tableaux.Catch a glipmse of this at Rajpath on this Republic day.last_img read more

Todays contest is between governance anarchy Jaitley

first_imgThe Union Finance Minister Arun Jaitley told voters that Friday’s contest is a ‘choice between governance and anarchy’.Jaitley’s statement was a reference from Aam Aadmi Party (AAP) Chief Arvind Kejriwal self claimed ‘anarchist’ statements two years back and Prime Minister Narendra Modi’s vision of good governance in the country. Speaking in a Press Conference at BJP headquarters, Jaitley said, “BJP will put all its effort for good governance as they are confident of winning the election. Delhi Assembly Poll holds importance because Delhi is the face of the country and how government runs here is a reflection of the country’s image.”While highlighting the development and governance in last eight months during BJP’s rule in the Centre, he said, “It should be noted that unlike previous regime, now no one talks of scams. The country, which was lagging behind, is now progressing. Now with the Delhi election almost knocking door, people have to choose between governance and anarchy.”last_img read more

Sikkim bureaucrat forgoes civil service to promote Bhoti calligraphy

first_imgDarjeeling: Jamyang Dorjee Chakrisar, a bureaucrat, gave up the corridors of power for his love for the Bhoti (Tibetan) language and calligraphy. Having taken voluntary retirement from civil service in Sikkim, Chakrisar took up the herculean duty of promoting Bhoti calligraphy.The Manjushree Centre of Tibetan Culture along with Tibetan Women’s Association and Regional Tibetan Youth Congress as a part of the Central Tibetan Administration’s “Thank You India 2018″ programme for the first time put up a three-day exhibition on Bhoti Calligraphy in Darjeeling. Also Read – Heavy rain hits traffic, flightsThe exhibition was held at the Manjushree Centre and Darjeeling Chowrasta.”The exhibition evoked immense response, specially among students and the youth. Many want to learn the nuances of this intricate art,” stated Ngawang Tenzing Gyatso, President of the Manjushree Centre.The programme also included an interesting talk by the Master calligrapher. “Bhoti, is the mother tongue of more than three million people living in seven states in the Himalayan regions ranging from Ladakh to Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedArunachal Pradesh. It is like the lingua franca. Bhoti needs to be included in the 8th schedule of the Indian Constitution,” stated Chakrisar.He stated that inclusion will not only mean national integration of the people of these far flung area but will also help promote a language that contributes in projecting the relevance of teachings of Nalanda.Bhoti (Tibetan) language is one of the most impressive translation histories of the world. Starting in the 8th century and continuing for around 900 years, they translated the entire Buddhist cannon, a body of work consisting of more than 4,500 texts and around 73 million words.National Mission for Manuscripts states “Tibetan scripts have outnumbered all other languages barring Sanskrit, Odia and Hindi.” The collection of Buddha’s teachings the Tripitaka, comprising 108 volumes and Tantras are available in Bhoti language and the names of all the volumes start with the word “Gyakar Keydhu” meaning “in the language of India.” “The translations have the potential to establish India as the Jagat Guru,” stated Chakrisar. The script was developed by Thonmi Sambhota in 7th century Nalanda.The Master Calligrapher has attended international level festivals in Japan, Bangkok, New York and will be attending the Congress of Calligraphy in France shortly. “I also promote Devanagri and the Great Indian civilisation at these international meets. I want to promote Yigtsel (Bhoti Calligraphy) on the lines of Sufa of China and Shodo of Japan,” he stated. He also holds the World record of creating the longest calligraphy scroll measuring 163 m in length with 65,000 characters using handmade Tibetan Lokta paper.His work focuses on u-med style where brushworks are exhibited freely. His other innovation is the depiction of Buddhist deities in miniature calligraphy.last_img read more

Talking on mobile phone while driving Other drivers pedestrians are watching

first_imgKolkata: Here’s a caution to those who talk on the cellphone while driving, flouting orders of the Kolkata Police. The city police have put up billboards to create awareness among drivers not to use mobile phones while driving as part of the Safe Drive Save Life programme. Despite such notices, drivers — both owners and professionals — continue to talk on mobile phones while driving.To curb this “unethical” practice, the city police has requested people to take photos of those who talk while driving and send it to the Facebook page of the Kolkata Police so that the errant drivers can be booked. Also Read – Heavy rain hits traffic, flightsIt may be recalled that both city and state police took elaborate steps to stop the malice of talking while driving after a bus plunged into a canal in Murshidabad after breaking the railings of Balirghat bridge under Daulatabad police station on January 30. It was learnt that the driver of the ill-fated bus was talking over the phone when the accident took place and refused to pay heed to the passengers who requested him not to talk over the phone while driving. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedChief Minister Mamata Banerjee who had gone to oversee the rescue operations asked the police to take stringent measures against those who talk over the phone while driving.A senior police officer said despite repeated requests, some car and two-wheeler drivers have refused to listen to the police and continue to talk over the phone while driving. It is detrimental to the driver as well as to the pedestrians and drivers of other vehicles. Because the driver is busy talking, his mind is somewhere else and he also cannot hear any sound around him. “The new step is likely to be effective as pedestrians and passengers of other vehicles have been asked to cooperate with the police to put an end to this ‘unhealthy’ culture.”last_img read more